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CELL & TISSUE

Tissue Engineering

Innovative Track-Etched Membranes Enable High Cell Recovery for Replacement Tissues & Organs

Filtration solutions
Tissue engineering
Oxyphen’s track-etched membrane technology offers the ideal support material to grow and harvest cells in tissue engineering applications.

Tissue engineering is the combination of life science and engineering mechanisms to create artificial organs, skins, and tissues that address pharmaceutical, regenerative medicine, diagnostics, and research applications.

Tissue engineering involves scaffolds, active biomolecules, and cells. The ultimate goal is to develop tissues and organs for replacement.

Oxyphen’s track-etched membrane technology offers the ideal support material to grow and harvest your cells. Our PET membranes in different pore sizes allow easy adjustment to the environments that different cell types require. Cell attachment, fluorescence imaging quality, and cell-barrier assay suitability determine the stable growth conditions and analysis.

  • Consistency and reproducibility of results
  • Excellent cell attachment and growth
  • High quality fluorescence imaging
  • High visibility of particles and cells
  • Backflushing allows reproducible sample recovery

  • Injection molding (2K)
  • Punch and welding
  • Cleanroom ISO class 7
  • Assembly
  • Packaging for OEM businesses

Rane Material Pore Size Application
PET small 0.4 um Co-Culturing
Drug Transport Studies
Secretion
Basolateral Diffusion
Cytotoxicity studies
PET large 3.0 – 8.0um Cell invasion
Chemotactic
Transport of larger molecules (lipoproteins, viruses)
Trans-endothelial migration
smooth muscle migration
PC TBD Please talk to one our experts for PC as a material option. 

 

Membrane Material Opacity Application
PET Translucent Electron Microscope
TEER
PET Transparent Light Microscope
Electron Microscope


Membrane Material # of wells
PET Multiwell plates (48 / 96 well)
PET

Multiwell plates (48 / 96 well)

 

Cell culture inserts (6 / 12 / 24 well)
Air Flow Up to 800 l / (bar cm2 min)
Pore Size 0.1µm to 10µm
Pore Density 0.01M to 1,000M pores per cm2
Thickness 8µm to 50µm
Temperature Range – 40°C and 160°C (up to 200°C)​
Hydrophilic Treatments Various hydrophilic treatments increase water flow rate and wetting abilities of the membrane
Sterilization procedures Stable against Gamma and X-ray
Specification Unique-Mem® Track-Etched Membranes RoTrac® Track-Etched Membranes
Bandwidth (mm)
10, 13, 14.5, 20 & custom sizes
High Quality Raw Materials
PET – naturally slightly hydrophilic
PC – naturally slightly hydrophobic
PET-Membrane/ PET-Nonwoven –harder
PET-Membrane/ PP-Nonwoven – softer
Pore Size Ranges
0.1µm to 10µm
0.2µm to 3.0µm
Pore Density Ranges
105 to 109 pores per cm2
2×106 bis 3×108 pores per cm2
Thickness Ranges
8µm to 50µm
90µm to 220µm
Temperature Ranges
– 40°C and 160°C (for special application < 200°C)
– 40°C and 130°C (for special application < 160°C)
Air Flow Ranges
Up to 800 l / (bar cm2 min)
Up to 37 l / (bar cm2 min)
Hydrophilic Treatments
Various hydrophilic treatments increase water flow rate and wetting abilities of the membrane (example: PVP treatment)
Hydrophobic / Oleophobic Treatment:
Grade up to 7.5; AATCC TM 118
Salt spray resistance test2
According to IEC 60068-2-52, based on validation by the customer
Temperature resistance test1
In accordance with ISO 16750-4
Ice water shock test1&2
In accordance with ISO 16750-4
Climate resistance test
In accordance with ISO 16750-4
Chemical resistance test1
According LV124/ ISO 16750-5
IP Protection1
IP 64/65/66/67/68, according to DIN 40050

1 Testing in Progress

2 Based on Customer Validation

Related Resources

Viral Filtration Efficiency (VFE) Certificate

Final test report from Nelson Labs for Viral Filtration Efficiency (VFE) at an Increased Challenge Level. Also available is the Bacterial Filtration Efficiency (BFE) report.

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Bacterial Filtration Efficiency (BFE) Certificate

Final test report from Nelson Labs for Bacterial Filtration Efficiency (BFE) at an Increased Challenge Level. Also available is the Viral Filtration Efficiency (VFE) report.

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Rollstock Membrane Product Brochure

Learn more about Oxyphen rollstock track-etched membrane material for in-house and large-scale manufacturing integration, which can be produced laminated or unlaminated, converted into different lengths, and surface treated upon request.

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Related Products

Rollstock Membrane

Rollstock Membrane

Ideally suited for in-house and large-scale manufacturing applications, Oxyphen’s track-etched Rollstock membrane can be laminated, unlaminated, or fiber-based – supplied from polyester (PET) or polycarbonate (PC) high quality raw materials.

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Assemblies & Modules

Assemblies & Modules

To meet specific product solution requirements within the life science and automotive spaces, Oxyphen engineers partner with leading OEMs to develop highly tailored components and assemblies for specific applications.

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Membrane Technologies Available

Unique-Mem track-etched membranes

Technologies

Unique-Mem® Unlaminated Track-Etched Membranes

Unique-Mem® track-etched membranes, available as hydrophilic or hydrophobic, are characterized by cylindrical shaped pores penetrating the membrane in different angles. They have a smooth flat surface and well-defined flow rates​.

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RoTrack Track-etched Membrane

Technologies

RoTrac® Laminated Track-Etched Membranes

Pre-punched hydrophobic or hydrophilic membrane discs in various dimensions. Easily mounted and produced using either hydrophobic or hydrophilic membranes for any filtration or venting application.

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